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The drug was approved by the US FDA in June 2021 as a 2.4 mg once-weekly injection for chronic weight management in adults with obesity or those overweight with at least one weight-related condition, such as high blood pressure, Type 2 diabetes or high cholesterol.3 In 2023, according to market information from Midas (IQVIA), sales of semaglutide for weight management more than quadrupled year-on-year, and further interest has been spurred by new indications related to reducing cardiovascular risk, and emerging benefits are being shown in people with Alzheimers disease.4,5 The strength of these figures clearly demonstrates the intense demand for GLP-1 treatments, but it does not convey the unforeseen implications of such high levels of popularity

For various reasons physicians may be reluctant to prescribe these medications, however with a thoughtful and respectful discussion, you may be able to advocate for yourself for their use

Hambright et al

Because the stomach holds onto food longer, you may feel excessively full, leading to waves of nausea, especially after eating high-fat or large meals

( j ) Representative 2D-classes from negative-stain, single-particle electron microscopy of GLP-1R/Ex4-S,S-X/DNGas/G1/G2/Nb35 complex