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3 Effects of incretins on the gastrointestinal tract Gut-released GLP-1 acts as a hormone and binds primarily to receptors in the gastrointestinal system

In a study, people who stopped Zepbound after 9 months (36 weeks) regained 14% of their lost weight

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Rybelsus tablets should be taken once daily, first thing in the morning on an empty stomach, with no more than 4 ounces of plain water, followed by a 30-minute wait before consuming food, beverages, or other medications

These steps allow the dose to go up slowly so patients can avoid most side effects