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also known as L1), has been tested in humans and is clinically used in Europe to treat thalassemia

42- Quinzii CM, Lopez LC, Gilkerson RW, Dorado B, Coku J, Naini AB, LagierTourenne C, Schuelke M, Salviati L, Carrozzo R, Santorelli F, Rahman S, Tazir M, Koenig M, DiMauro S, Hirano M (2010) Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency

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Participants that were prone to develop DRP had pre-existing DRP, longer diabetes duration, higher HbA 1c levels at baseline, and more often used insulin therapy

If you are already at maintenance dose, the overshoot is minimal, about 4% above target

24 October 2023