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This neutral, water-soluble substance is abundant in skeletal muscle, heart, brain, and pancreas

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Furthermore, the depletion of gut microbiota inhibits leptin signaling and food intake in mice fed with the normal diet, whereas inhibits food intake but without affecting leptin signaling in mice fed with the high-fat diet [39, 40], demonstrating that the effect of gut microbiota on leptin signaling is dependent on the diet