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The primary sensory neurons of the vagal afferents are located in the bilateral nodose ganglia (NG) that relay peripheral nerve signals from the gastrointestinal tract to the nucleus tractus solitarius (NTS) in the medulla oblongata

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In this longer-term study patients who had responded to VYVANSE in the preceding 12-week open-label treatment phase were randomized to continuation of VYVANSE or placebo for up to 26 weeks of observation for relapse

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