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Neither compound has an FDA-approved use, so there is no regulatory efficacy or safety determination to lean on
The study was sponsored by Eli Lilly and Company, the manufacturer of orforglipron and the injectable GLP-1 tirzepatide
Also, other orexigenic (appetite-stimulating) hormones such as Ghrelin may increase or rebound, offsetting GLP-1 effects [18]
The published evidence does not support that level of specificity
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