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demonstrated a 29% higher drug uptake than non-targeted liposomes and a superior impact on disease delay when delivered by the intracerebroventricular route in ALS mice (124, 125)

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Sorensen M, Sanz A, Gmez J, Pamplona R, Portero-Otn M, Gredilla R, Barja G: Effects of fasting on oxidative stress in rat liver mitochondria

In Vivo Activity Duration and Dosing Implications The preclinical dosing regimen provides indirect evidence about the peptide's functional duration in vivo, though formal pharmacokinetic parameters remain unmeasured