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Related Molecular Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists in Osteoporosis Glucagon-Like Peptide-1 Receptor/cAMP/PI3K/AKT Signal Pathway The PI3K/AKT signaling pathway plays an important role in regulating proliferation, osteoblast differentiation and osteoclast differentiation, apoptosis (Figure 1)