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GLP-1 receptor agonists semaglutide , liraglutide , and tirzepatide have transformed the treatment of obesity and type 2 diabetes
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Notably, in high-quality large RCTs, tirzepatide demonstrated greater effectiveness than GLP-1R mono agonists in reducing serum glucose, fat mass, and body weight
cite Key differences at a glance Administration and adherence: Injectables are usually once-weekly pens you inject under the skin, while approved oral semaglutide is a daily tablet taken on an empty stomach with strict timing rules
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