If liver fat reduction is a key objective, retatrutide offers substantially greater hepatic fat clearance than tirzepatide, as discussed above
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The benchmark to evaluate at week 12 is whether you have achieved at least 5% body weight loss from your starting point
N Engl J Med 2023;389:1069-1084
GLP-1 medications also reduce blood pressure, improve lipid profiles, decrease systemic inflammation, and show renal protective effects