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Under physiological conditions, the cyclic recruitment of primordial follicles and the gradual reduction in oocyte quality result in a year-by-year decrease in ovarian reserve, ultimately leading to its exhaustion after menopause

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93 In their model, cydD mutants had reduced trimethoprim uptake, which was reversed by deleting acrAB or by restoring GSH (74)

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A total of 1,638 differential genes were obtained through differential analysis, including 672 upregulated genes and 966 downregulated genes (Figure 3C)

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