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The standard dosing protocol is 1.6 to 3.2 milligrams per week, administered subcutaneously

21 Mechanistically, the presence of GLP-1 receptors in the retina raises the possibility of a direct toxic effect of the GLP-1/GIP agonists leading to the observed retinopathy progression

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Its activity profile is best understood as systems-level polypharmacology rather than single-receptor agonism: published research has documented effects on nitric oxide system signalling, growth-factor receptor expression (including VEGF receptor 2 and growth-hormone receptor), dopamine and serotonin pathway markers, and angiogenic factor regulation

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