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Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12

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49 Furthermore, the constitutive expression of claudin-1 in gut epithelium in mice resulted in decreased claudin-7 expression and enhanced susceptibility to acute colitis

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The evidence pattern from user experiences places acute soft tissue injuries at the top of the response hierarchy (60 to 70% report clear benefit), followed by muscle strains, gastrointestinal issues, and post-surgical recovery

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