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The pharmacologic superiority of parenteral vitamin B12 to oral supplementation with large doses of cobalamin has never been adequately demonstrated
Subsequent hematologists noted characteristics of megaloblastic anemia in the peripheral blood (ie, macrocytes, poikilocytes, and hypersegmented neutrophils) and bone marrow (eg, megaloblasts, meta-myelocytes, and megakaryocytes) (139)
The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant
This condition stops the body from absorbing vitamin B12 because of a lack of intrinsic factor