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On the other hand, the treatment policity estimand was used to evaluate the treatment effect for all randomized participants regardless of whether the trial was discontinued early or rescue medicien was used [2]

It functions as a cofactor for lysyl oxidase (the enzyme responsible for collagen cross-linking and stabilization), ceruloplasmin (a copper transport protein with antioxidant activity), and superoxide dismutase (SOD, a primary antioxidant defense enzyme)

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