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Recent observations highlighted the critical association with intestinal flora, as confirmed by the finding that metformin decreased the relative abundance of Bacteroides fragilis while increasing Akkermansia muciniphila and Bifidobacterium bifidum
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Combining Cerebrolysin with NAD+ infusions, complementary neuropeptides, and lifestyle protocols including regular aerobic exercise (a potent natural BDNF booster), quality sleep optimization, and anti-inflammatory nutrition may support a more comprehensive environment for brain health optimization
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As IGF-1R mAbs are readily available for human use, these observations warrant further study into potentially harnessing these drugs to target at least some manifestations of aging
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