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What sets tirzepatide apart is that it is a first-in-class dual agonist: it activates two gut-hormone receptors at once (GIP and GLP-1), whereas semaglutide targets GLP-1 alone
For people taking these medications, this means they must be careful to ensure that theyre still consuming a healthy spread of micro and macro nutrients on a daily basis
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The main difference is that tirzepatide tends to produce more significant appetite suppression due to its dual-receptor mechanism, so semaglutide users may find they can tolerate slightly larger portions
