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Moreover, the CPRD data are not publicly available, and the analysis plan requires specialised training

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The direct action of GIP on its receptor, which is expressed by these cells, is what causes GIP stimulation to increase glucagon secretion by alpha cells in contrast to GLP- 1 [72,73,74]

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The resulting elevation in intracellular Ca activates protein kinase C (PKC), which subsequently phosphorylates and activates MEK, ultimately leading to enhanced phosphorylation and activation of ERK1/2 within the MAPK pathway [51] [52](Fig