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In research it is studied for sleep-architecture pathway research, hypothalamic-pituitary axis modulation, and stress-response signaling
It is also involved in the activation of the synthesis of matrix compounds in vivo, which are critical for the formation of a resistant new tissue [12-13]
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A local synthesis of estradiol by endometriotic tissue is suggested by the evidence of increased aromatase activity, associated with an overexpression of cyclooxygenase 2 (COX2) and increased prostaglandins
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