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In 3T3-L1 adipocyte cell models, 5-Amino-1MQ at 30 M concentration produced significant reductions in intracellular 1-MNA levels, confirming target engagement

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doi: 10.1590/1806-9282.65.8.1094 38 SeibtT

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In this regards, we have shown earlier that reducing conditions favor activation of primary human T-cells (15), whereas oxidative stress leads to hyporesponsiveness or even cell death of primary human T-cells (16, 17)

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