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The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves
There are also several non-catalytic antioxidant proteins such as the glutaredoxins, the thioredoxins (Trx), and the metallothioneins (MT)
Smoking or heavy alcohol use: These behaviours increase baseline cancer risk
The drug degraded under certain preparation conditions, limiting available processing options
Pre-mixed retail cosmetic serums contain unknown or trace concentrations of GHK-Cu, heavily mixed with stabilisers, fragrances, and preservatives
Crockford, D., et al
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