Resistin upregulates P-selectin and fractalkine in HECs in response to high glucose stimulation, which leads to oxidative stress through Nox-mediated ROS production and increases monocyte adhesion through the activation of NF-B and AP-1 [76]
Disadvantages (What few talk about): Unstable: It oxidizes quickly (turns brown) and loses its effectiveness
no Phase II or III trials published Most common AOD-9604 side effect / Injection-site reaction (redness, swelling) Most common reported MOTS-c side effect / Transient flushing and mild GI discomfort (anecdotal, not trial-confirmed) Growth hormone axis impact / AOD-9604 does not activate the GH receptor
Gastrointestinal upset: Some people experience a bit of abdominal cramping or bloating during or after the infusion
Examples of dietary antioxidants sources include curcumin, brassinosteroids, gallocatechins, resveratrol, etc
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