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Acetylcysteine itself may cause some prolongation of INR
Antioxidant supplementation during chemotherapy should only occur under oncological supervision
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Doxorubicin stock solution (10 mM, 100% DMSO) was serially diluted in unbuffered seahorse assay medium to prepare 6 concentrations: 400, 300, 200, 100, 80 and 40 M
When IGF1 binding to IGF-IR/InsR is blocked by the anti-IGF-IR mAb cixutumumab, IGF1 binding to integrin v3 increases, resulting in activation of v3 and its downstream effectors Src, FAK, and PI3K, which confers cixutumumab resistance [172]
They can also lead to muscle loss, which would be concerning for SUD patients if the off-target effects continue outside of obesity and diabetes
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