CC: Conceptualization, Data curation, Writing original draft
Glucagon receptor activation is thought to increase energy expenditure and promote fat breakdown (lipolysis), which may help explain the substantial weight loss observed in early-phase trials however, these mechanistic effects have not yet been fully characterised in humans and should be regarded as preliminary findings
SGLT-2 drugs still have a major role The headline number favors GLP-1 drugs, but the medical decision is not winner-takes-all
(PubMed) Bargossi AM, Battino M, Gaddi A, et al
PMID:39161060 Liu M, et al
Um, and so all of those things impact the activation of our hormones