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Mariani, R., Trombini, P., Pozzi, M

Targeted management strategies include starting with a low dose and gradually increasing it, taking the medication after meals to reduce gastrointestinal discomfort, and optimizing diet (e.g., avoiding high-fat foods) (Wharton et al., 2022)

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Split doses can be helpful, as large amounts of vitamin C can sometimes cause gastrointestinal discomfort