Still, through different sub-mechanisms: Sermorelin is a GHRH analog similar in concept to Tesamorelin (though shorter and less stable), while Ipamorelin is a ghrelin-mimetic that stimulates GH release through a separate receptor
Add the fact that no large randomized trial has compared the combination against either agent alone, and there is no clean way to attribute anyone's outcome to the pairing
Heald AH, Anderson SG, Ivison F, Laing I, Gibson JM, Cruickshank K
Neurotrauma 12, 929932
Because absorption may be limited, higher doses are often recommended to achieve noticeable benefits
For Stronger Bones and Joints Collagen As you age, your joints become stiffer and less flexible