Signs that insulin may be needed include persistently elevated blood sugar despite maximum GLP-1 doses, declining endogenous insulin production, and treatment plateaus that suggest the incretin-based approach has reached its limits
Ongoing research is focused on multi-target agonists, oral drugs, and broader therapeutic applications beyond diabetes and obesity, including cardiovascular, kidney, liver, and neurodegenerative conditions
O.AronstamR
Seek immediate medical help if tremors occur with confusion, loss of consciousness, chest pain, or sudden neurological symptoms
Association of semaglutide with risk of suicidal ideation in a real-world cohort
A lot of smart people try things after seeing a hundred glowing reviews