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Intermittent fasting Caloric restriction and intermittent fasting increase BDNF expression, likely through metabolic stress pathways that trigger adaptive neuronal responses

in a clinical trial at the Royal Victoria Hospital in Montreal in 1980-1981 12

short sequential cohort about -4.7% during the initial 2.5 mg phase and -12.7% by the end of the 5 mg phase (Barrea EXCLI Journal 2026)

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Ormsbee, H S 3rd, and J D Fondacaro

Tumours were induced, and upon presentation of clinical symptoms of tumour burden, animals were randomized and treated with 150 mg kg 1 5FU three times per week, with 250 mg kg 1 metformin or vehicle control delivered concurrently (Fig