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Ethics declarations Ethical approval The experiment was approved by the Institutional Animal Ethics Committee (IAEC) with the protocol numbers 1930/1990

Mann-Whitney U-Rank Sum test (Table 5)

declare a US patent No US10888577B2: PCT international patent WO2017143430A1, entitled MiRNA biomarkers for cartilage degeneration

What is clear is that factors such as UV exposure and immunosuppression also play a role

However, other studies have confirmed that Ex-4 induces apoptosis in breast cancer cells by regulating genes associated with cell survival and the extrinsic apoptotic pathway [74]