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Those on tirzepatide lowered their A1c by 2-2.3 percentage points (depending on injection dose) compared to those on semaglutide who achieved a reduction of 1.86 percentage points (with 1 mg weekly injections)

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Unexpectedly, we found that GLP-1 WT bound human FcRn 5-fold more strongly than unfused WT albumin at acidic pH, due to both faster association and slower dissociation