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31,32,33 Discovery of granulocyte colony-stimulating factor Granulocyte colony-stimulating factor (G-CSF) is a cytokine synthesized by both non-hematopoietic and hematopoietic cells, exerting a pivotal influence on the regulation of granulocyte proliferation, differentiation, and mobilization from the bone marrow

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Any new or worsening symptoms after months of stable therapy should be evaluated, as these may indicate complications unrelated to expected medication effects

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