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This oxidized form is reversed by thioredoxin (Trx)/Trx reductase/NADPH system, although, in RBCs, it is a very slow regeneration due to the low concentrations of Trx reductase [73]

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Both GSH and CME also tend to chelate with copper ions, and their respective conformations are GSH_a and CME_a, which interact with residues in the C1 region

Molecular pathways associated with oxidative stress in diabetes mellitus