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Although the precise mechanism by which these LXR agonists effect a reduction in the progression of atherosclerosis is not clear, it is known that the genes encoding ABCA1 and ABCG1 contain LXR-binding sites
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These enzymes leak into the blood when liver cells are stressed or damaged, so they serve as a warning sign
However, in specific contexts, GLP-1 has also been shown to exhibit cytotoxic effects
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The body weight of mice and food intake were recorded daily
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