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Maintaining potency over weeks in a depot (and over months/years on the shelf) requires innovative formulation

Seek medical attention promptly for severe abdominal pain, repeated vomiting, trouble breathing, swelling of the face or throat, severe dehydration, or symptoms of low blood sugar

Start with smaller quantities and assess tolerance

Total Loss: By the six-month mark, many patients have lost 10% of their body weight . Plateau Alert: It is very common to see a stall around month five

Hormonal fluctuations can make women more susceptible to shifts in fluid balance, particularly related to their menstrual cycle

Acknowledgements PSA is supported by the American College of Medical Genetics Foundation/Genzyme 2014-2015 Fellowship in Biochemical Genetics