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Given that L-carnitine uptake into skeletal muscle occurs slowly and is influenced by insulin availability and training status, chronic exposure to elevated plasma LC levels may eventually reduce the responsiveness of transport mechanisms or alter carnitine homeostasis

Long-term safety and efficacy data remain limited for both agents, as most clinical trials have been of relatively short duration

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Most side effects occur within hours to a day after injection and usually disappear quickly

Formulation R2 follows a similar schedule