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10.1124/jpet.116.237503 388 SanghaiN.TranmerG
In-use vials can remain at room temperature for limited periods, but refrigeration maximizes stability and shelf life
Frequently, animals were on an ad libitum feeding regime outside the scope of the experiments, where postprandial processes were left uncontrolled
These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione
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