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When impaired, ERAD is associated with the development of various diseases, such as cancer, metabolic and genetic diseases, and neurodegenerative disorders (Fig
In TRIUMPH-1, treatment discontinuations due to adverse events occurred at 4.1%, 6.9%, and 11.3% on the 4 mg, 9 mg, and 12 mg arms respectively, compared with 4.9% on placebo [2]
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No large-scale randomised controlled trials have directly examined probiotic efficacy in this specific population , though related research provides some context
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