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Clinical trials have shown that dual agonists significantly reduce hepatic fat and NASH progression

Outcomes vary: Mild cases may improve with treatment Moderate cases may require long-term management Severe cases can become permanent Some patients develop lifelong GI dysfunction after GLP-1 drug use Early diagnosis significantly improves prognosis

Wnt signaling, influencing cell fate determination and proliferation

The Missing Link: While most liver cells lack GLP-1 receptors, a specific subset of endothelial cells lining the liver's blood vessels (sinusoids) actually have them

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Its introduction into clinical practice marks a shift towards integrated treatments that address the multifaceted nature of metabolic diseases