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The safety profile remained consistent across different dose levels, administration routes, and treatment durations

Most medical professionals will recommend alternate injection sites to avoid scarring and irritation

Anything less than 200 pg/ml is generally considered to be a deficiency

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31 Since the 2021 review, one more RCT has been published that compared oral B12 alone, 25 g per day (form not reported), or with folate (800 g per day) versus no supplements for 6 months in patients with mild cognitive impairment

B12 is only found in animal products (meat, eggs, shellfish, dairy), making deficiency especially common among vegans and vegetarians