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[133] [92] Industrial [edit] Industrial production of B 12 is achieved through fermentation of selected microorganisms

Peripherally, pancytopenia is most often observed, but only 1-2 of the major cell types (erythrocytes, leukocytes, platelets) may be depressed in some cases

[3] : 313 The most common cause in developed countries is impaired absorption due to loss of gastric intrinsic factor (IF), required for absorption