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Preserving lean muscle supports metabolic health and long-term results

As clinical data for both anti-PCSK9 antibodies and GLP-1 analogue molecules are widely available, we used PK-PD modelling to determine the appropriate potency at human GLP-1R for the fusion molecule that should deliver robust glucose control without inducing non-manageable GLP-1 driven adverse events at exposure levels able to efficiently neutralize PCSK9

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N Engl J Med 391:109121

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No, retatrutide is still an investigational medication and has not yet received FDA approval