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For topical-only GHK-Cu users on metformin, this monitoring protocol is not necessary
For example, the acetylation-deficient TP53 variant, TP53[3KR], lacks the ability to induce apoptosis and cell cycle arrest but retains its tumor suppression function akin to wild-type TP53
If you experience dryness or sensitivity, consider using GHK-Cu every other day or alternating days with your retinoid
Therefore, the PYR method can accurately detect methylation variants at different loci
Horiuchi T, Onouchi T, Takahashi M, et al
& Mugesh, G
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