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He noted that the final daily dose of liraglutide in the IDegLira group averaged 1.4 mg, compared with 1.8 mg in patients randomized to GLP-1 agonist monotherapy

The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]

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This means changes must be tracked in the CMC (chemistry, manufacturing, controls) sections of INDs/NDAs, adding a layer of oversight