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These diverse mechanisms are some of the hidden players responsible for the onset of cardiac remodeling which most frequently manifests as early-on asymptomatic diastolic dysfunction that later progresses into more severe pathological phenotype ( 2.1 Remodeling and fibrosis in DCM Long-term T2DM promotes proliferation of cardiac fibroblasts leading to interstitial extracellular matrix (ECM) deposition and myocardial interstitial fibrosis which contributes to LV anatomic and functional remodeling (39)
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21 Given this critical findings, The ADA advises using GLP-1 RAs to treat type 2 diabetes in adults with MASH, citing histological benefits demonstrated in the mentioned phase 2 randomized controlled trials
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