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In This Article Both Trulicity and Ozempic are GLP-1 receptor agonists Both Trulicity (dulaglutide) and Ozempic (semaglutide) are GLP-1 receptor agonists that work the same way
As a triple agonist , it simultaneously activates three distinct receptor systems [5]: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors enhance insulin secretion and may have direct effects on adipose tissue GLP-1 (Glucagon-like Peptide-1) receptors promote satiety, slow gastric emptying, and improve glucose regulation Glucagon receptors increase energy expenditure and may enhance fat oxidation This multi-receptor targeting strategy distinguishes retatrutide from single-pathway peptides and creates a complex metabolic profile that researchers are still working to fully characterize
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Eur J Pharmacol 265 : 17 Patacchioli FR, Amenta R, Ramacci MT, Taglialatela G, Maccari S, Angelucci L