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Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial

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Precautions for Sensitive Groups: Patients with a history of mental health conditions, diabetic retinopathy, or cardiovascular conditions should discuss these with their provider before starting

2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: Developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC)

This change makes the molecule too hydrophilic to cross BBB, therefore high dose is needed for CNS application [16]