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One animal in the single MEDI7219 10 mg dose group for the glucose tolerance test was excluded from analysis due to a likely error in dosing

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The medication should be kept in its original carton to protect it from light exposure, which can degrade the peptide structure

A semi-logarithmic plot of the fraction of noninhibited enzyme activity ln( v i / v 0 ) versus incubation time yielded linear curves with increasing slopes, equivalent to the apparent rate constant of irreversible inhibition ( k obs ) in GR (Figure 4A) and in TrxR (Figure 4C) assays