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The activity of the mitochondrial enzyme, glutamate dehydrogenase (GDH) was measured using the GDH assay kit (Abcam, Cambridge, United Kingdom)

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Crucially, they discovered a direct, measurable inverse relationship between CoQ10 levels and the severity of the patients' clinical symptomsthe lower the CoQ10 levels dropped, the more severe the patients' fatigue, autonomic dysfunction, and neurocognitive impairments became