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Pertea G
In murine models of PDAC with Kras and Tp53 mutations, Smad4 functionally interacts with Tp53 and Kras
In addition, if you have a BMI of 27 or higher as well as at least one weight-related condition, such as high blood pressure, high cholesterol, or osteoarthritis, you can also qualify for semaglutide treatment for weight loss
Although additional studies are warranted, the curli protein is also known to promote aggregation and neurodegeneration of amyloid-, SOD1-G85R, and huntingtin in AD, ALS, and Huntington disease models, respectively (Wang et al., 2021)
This has been observed as a secondary benefit alongside the reduction in insulin resistance and the reduction in obesity
