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Nunes, S

doi:10.1038/sj.ijo.0801740

There is also what they call a plateau like with topical products that your body becomes immune to it and it's not as effective as before

Ipamorelin acts as a third amplifier: it's a selective ghrelin receptor agonist with minimal effect on cortisol or prolactin (the side-effect profile that plagues older GHRPs like GHRP-6)

10.1046/j.1365-313x.1998.00319.x 133 SamsatlyJ.CopleyT

Oxidation and other chemical degradation: BPC-157 does not contain cysteine, the most oxidation-sensitive residue in many peptides, so the dominant oxidative risk is lower than for cysteine-containing sequences